ABSTRACT
Objective To establish the SD rat aortic dissection(AD)model by using both BAPN and AngⅡ,in order to investigate AD's pathogenesis. Methods 90 three weeks old SD rats were equally divided into three groups randomly:control group,medicine gavage group and blank medicine gavage group. Rats in control group were fed on a regular diet;BAPN ( 1g/ kg per day)was forced into rats'stomach in the medicine gavage group;the same volume saline was forced into rats' stomach in the blank medicine gavage group. 4 weeks later,when the rats were 7 weeks old,we stopped giving them BAPN, but to implant an omicro-osmotic pump subcutaneously in the abdomen. The pumps in control group and blank medicine gavage group were filled with 0. 9％ saline,the medicine gavage group'pumps were filled with AngⅡsolution( 1 μg·kg- 1 ·min- 1 ). 1 week later,all the survivals were dissected after anesthesia and the aortic vessels were acquired. All the acquired aortic ves-sels were proceed pathological examination. All the rats dead during the process of the experiment were dissected immediately to get the aortic vessels and proceed pathological examination. Results All rats in control group and blank medicine gavage group were survival,there was no aortic dissection or death. In medicine gavage group, 15 rats developped aortic dissection, 12 a-mong them were died of aortic dissection rupture,the aortic dissection formation rate was 50％ . Conclusion Using BAPN and AngⅡ to establish the SD rat AD model is feasible,it is simple and practicable,meanwhile,it has high aortic dissection for-mation rate. The process is similar with human's aortic dissection process.
ABSTRACT
Objective To analyze clinical features of secondary hypertension in children,and explore the etiology of secondary hypertension and improve the clinical diagnosis and treatment.Method Retrospective analysis of the clinical features in 120 children with secondary hypertension was performed.Results 1.Seventy-nine patients (65.8％,79/120 cases) were male,41 patients(34.2％,41/120 cases) were female.The mean age was (9.5-±4.1)years old.2.Main clinical manifestations:55 cases of edema (45.8％,55/120 cases),52 cases of seizure (43.3％,52/120 cases),49 cases of headache (40.8％,49/120 cases),44 cases of vomit (36.7％,44/120 cases),33 cases of dizziness (27.5％,33/120 cases),24 cases of oliguria (20.0％,24/120 cases).3.Seventy-seven patients (64.2％,77/120 cases) were renal hypertension,22 patients (18.3％,22/120 cases) were drug-induced hypertension,5 patients (4.2％,5/120 cases) were endocrine disease,4 patients (3.3％,4/120 cases) were rheumatic disease,3 patients (2.5 ％,3/120 cases) were cardiogenic disease,2 patients (1.7 ％,2/120 cases) were neuroblastoma.4.Seventy-one patients (59.2％,71/120 cases)were complicated with hypertensive encephalopathy,among them 47 patients (66.2％,47/77 cases)were acute glomerulonephritis.5.One hundred and eleven patients' blood pressure turned to normal after treatment of the primary diseases.The other 9 patients were discharged because they abandoned treatment.Conclusions Renal disease is the most common etiology of secondary hypertension in children.Children with secondary hypertension are easily complicated with hypertensive encephalopathy.The key of treatment is early diagnosis and early treatment of primary diseases.